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anti fhr 4 monoclonal mouse antibody  (R&D Systems)


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    R&D Systems anti fhr 4 monoclonal mouse antibody
    Anti Fhr 4 Monoclonal Mouse Antibody, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti fhr 4 monoclonal mouse antibody/product/R&D Systems
    Average 93 stars, based on 3 article reviews
    anti fhr 4 monoclonal mouse antibody - by Bioz Stars, 2026-06
    93/100 stars

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    Complement Markers’ Information.

    Journal: PLoS ONE

    Article Title: Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

    doi: 10.1371/journal.pone.0159828

    Figure Lengend Snippet: Complement Markers’ Information.

    Article Snippet: 8 , CFHR4 , 65 kDa , Mouse anti-Factor H-related 4 (CFHR4) Monoclonal antibody #MAB5980 (RD Systems) , 1:1000 , Human , Anti-mouse IgG, HRP-linked antibody #7076 (CST) , beta-actin antibody GTX 110564 (Genetex).

    Techniques: Marker, Activation Assay, Lysis, Inhibition

    Journal: PLoS ONE

    Article Title: Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

    doi: 10.1371/journal.pone.0159828

    Figure Lengend Snippet: Complement Proteins’ Western Blotting Information.

    Article Snippet: 8 , CFHR4 , 65 kDa , Mouse anti-Factor H-related 4 (CFHR4) Monoclonal antibody #MAB5980 (RD Systems) , 1:1000 , Human , Anti-mouse IgG, HRP-linked antibody #7076 (CST) , beta-actin antibody GTX 110564 (Genetex).

    Techniques: Western Blot

    The classical pathway is triggered by interaction of C1 with immune or non-immune complexes leading to conformational changes in C1q, activation of C1r and C1s, and subsequent assembly of C3 convertase. The lectin pathway is activated by binding of mannose-binding lectin (MBL) to mannose residues on the pathogen surface, which activates the MBL-associated serine proteases (MASPs), followed by formation of C3 convertase. Spontaneous hydrolysis of C3 initiates the alternative complement pathway. All three pathways of the complement cascade converge on the classical C3 convertase, which cleaves and activates component C3, forming C3a and C3b. This triggers a series of further cleavage and activation events, leading to cleavage of C5 into C5a and C5b, and eventual formation of the membrane attack complex (MAC), consisting of C5b, C6, C7, C8, and C9. MAC is the terminal cytolytic complex of the complement pathway; it causes osmotic lysis of target cells by forming transmembrane channels that disrupt the phospholipid bilayer of target cells. The complement system is tightly regulated by the following complement control proteins: CFH, CFHR1, CFHR4, CFB, CD55, CD59, CD46, CFI, and CFP.

    Journal: PLoS ONE

    Article Title: Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

    doi: 10.1371/journal.pone.0159828

    Figure Lengend Snippet: The classical pathway is triggered by interaction of C1 with immune or non-immune complexes leading to conformational changes in C1q, activation of C1r and C1s, and subsequent assembly of C3 convertase. The lectin pathway is activated by binding of mannose-binding lectin (MBL) to mannose residues on the pathogen surface, which activates the MBL-associated serine proteases (MASPs), followed by formation of C3 convertase. Spontaneous hydrolysis of C3 initiates the alternative complement pathway. All three pathways of the complement cascade converge on the classical C3 convertase, which cleaves and activates component C3, forming C3a and C3b. This triggers a series of further cleavage and activation events, leading to cleavage of C5 into C5a and C5b, and eventual formation of the membrane attack complex (MAC), consisting of C5b, C6, C7, C8, and C9. MAC is the terminal cytolytic complex of the complement pathway; it causes osmotic lysis of target cells by forming transmembrane channels that disrupt the phospholipid bilayer of target cells. The complement system is tightly regulated by the following complement control proteins: CFH, CFHR1, CFHR4, CFB, CD55, CD59, CD46, CFI, and CFP.

    Article Snippet: 8 , CFHR4 , 65 kDa , Mouse anti-Factor H-related 4 (CFHR4) Monoclonal antibody #MAB5980 (RD Systems) , 1:1000 , Human , Anti-mouse IgG, HRP-linked antibody #7076 (CST) , beta-actin antibody GTX 110564 (Genetex).

    Techniques: Activation Assay, Binding Assay, Membrane, Lysis, Control

    Complement Markers’ Information.

    Journal: PLoS ONE

    Article Title: Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

    doi: 10.1371/journal.pone.0159828

    Figure Lengend Snippet: Complement Markers’ Information.

    Article Snippet: 8 , CFHR4 , 65 kDa , Mouse anti-Factor H-related 4 (CFHR4) Monoclonal antibody #MAB5980 (RD Systems) , 1:1000 , Human , Anti-mouse IgG, HRP-linked antibody #7076 (CST) , beta-actin antibody GTX 110564 (Genetex).

    Techniques: Marker, Activation Assay, Membrane, Lysis, Inhibition

    Complement Genes’ Information.

    Journal: PLoS ONE

    Article Title: Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

    doi: 10.1371/journal.pone.0159828

    Figure Lengend Snippet: Complement Genes’ Information.

    Article Snippet: 8 , CFHR4 , 65 kDa , Mouse anti-Factor H-related 4 (CFHR4) Monoclonal antibody #MAB5980 (RD Systems) , 1:1000 , Human , Anti-mouse IgG, HRP-linked antibody #7076 (CST) , beta-actin antibody GTX 110564 (Genetex).

    Techniques: Variant Assay

    Complement Proteins’ Western Blotting Information.

    Journal: PLoS ONE

    Article Title: Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

    doi: 10.1371/journal.pone.0159828

    Figure Lengend Snippet: Complement Proteins’ Western Blotting Information.

    Article Snippet: 8 , CFHR4 , 65 kDa , Mouse anti-Factor H-related 4 (CFHR4) Monoclonal antibody #MAB5980 (RD Systems) , 1:1000 , Human , Anti-mouse IgG, HRP-linked antibody #7076 (CST) , beta-actin antibody GTX 110564 (Genetex).

    Techniques: Western Blot

    Complement Gene Expression Data.

    Journal: PLoS ONE

    Article Title: Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

    doi: 10.1371/journal.pone.0159828

    Figure Lengend Snippet: Complement Gene Expression Data.

    Article Snippet: 8 , CFHR4 , 65 kDa , Mouse anti-Factor H-related 4 (CFHR4) Monoclonal antibody #MAB5980 (RD Systems) , 1:1000 , Human , Anti-mouse IgG, HRP-linked antibody #7076 (CST) , beta-actin antibody GTX 110564 (Genetex).

    Techniques: Gene Expression

    Decreased protein levels of CFH, CFHL1, CD55, CD59, CFI, and CD46, and increased levels of CFP, CFB, CFHR4, and CFHR1 protein in AMD cybrids. (A, C, E, G, I, K, M, O, Q, S) Representative Western blots of CFH, CFHL1, CD55, CD59, CFI, CFP, CFB, CD46, CFHR4, and CFHR1 respectively. (B, D, F, H, J, L, N, P, R, T) Graphs showing quantitation of CFH, CFHL1, CD55, CD59, CFI, CFP, CFB, CD46, CFHR4, and CFHR1 proteins in Older-Normal and AMD cybrids. * P < 0.05, ** P < 0.01. n = 4–5. Data were analyzed using Student’s T-test.

    Journal: PLoS ONE

    Article Title: Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

    doi: 10.1371/journal.pone.0159828

    Figure Lengend Snippet: Decreased protein levels of CFH, CFHL1, CD55, CD59, CFI, and CD46, and increased levels of CFP, CFB, CFHR4, and CFHR1 protein in AMD cybrids. (A, C, E, G, I, K, M, O, Q, S) Representative Western blots of CFH, CFHL1, CD55, CD59, CFI, CFP, CFB, CD46, CFHR4, and CFHR1 respectively. (B, D, F, H, J, L, N, P, R, T) Graphs showing quantitation of CFH, CFHL1, CD55, CD59, CFI, CFP, CFB, CD46, CFHR4, and CFHR1 proteins in Older-Normal and AMD cybrids. * P < 0.05, ** P < 0.01. n = 4–5. Data were analyzed using Student’s T-test.

    Article Snippet: 8 , CFHR4 , 65 kDa , Mouse anti-Factor H-related 4 (CFHR4) Monoclonal antibody #MAB5980 (RD Systems) , 1:1000 , Human , Anti-mouse IgG, HRP-linked antibody #7076 (CST) , beta-actin antibody GTX 110564 (Genetex).

    Techniques: Western Blot, Quantitation Assay

    Complement Protein Expression Data.

    Journal: PLoS ONE

    Article Title: Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids

    doi: 10.1371/journal.pone.0159828

    Figure Lengend Snippet: Complement Protein Expression Data.

    Article Snippet: 8 , CFHR4 , 65 kDa , Mouse anti-Factor H-related 4 (CFHR4) Monoclonal antibody #MAB5980 (RD Systems) , 1:1000 , Human , Anti-mouse IgG, HRP-linked antibody #7076 (CST) , beta-actin antibody GTX 110564 (Genetex).

    Techniques: Expressing